MERCEDES-BENZ E 350 · model year

2021 MERCEDES-BENZ E 350

17 NHTSA complaints, and 6 active recalls for this specific cohort.

NHTSA overall rating

Not crash-tested

New Car Assessment Program

The 2021MERCEDES-BENZE 350 carries 17 consumer safety complaints in NHTSA's Office of Defects Investigation database for this specific model-year cohort. Within that volume, owners reported 0 crashes, 2 fires, 0 injuries, and 0 fatalities. No NCAP 5-star crash-test rating is available for this model year in the federal database.

Component-level analysis is where model-year complaints become actionable: the top complaint category for the 2021 E 350 is engine with 4 filings, followed by electrical system (3) and back over prevention: warnings (2). Concentration in one or two component groups is the classic signature of a systemic defect; a flat distribution usually reflects normal aging, warranty complaints, or isolated build-plant variability. This model year has 6 active recall campaigns, which means the manufacturer is obligated to remedy the covered defect at no charge for the life of the vehicle — the full NHTSA campaign numbers are listed below.

NHTSA currently has 15 investigation files overlapping the 2021 E 350. Owners comparing this cohort against neighboring years should pair the counters above with the complaint-by-year trend on the parent model page — a spike in a single year often tracks to a platform refresh, a new transmission supplier, or an updated ECU calibration. Use the related-complaint feed below to read raw owner narratives before deciding whether any pattern here affects your specific use case.

17
Complaints
0
Crashes
2
Fires
0
Injuries
0
Deaths

Total Complaints

17 filings

Crashes Reported

0 reports

Source

NHTSA ODI

Federal complaints database

Complaints vs. fleet median (215)

At or below the fleet median complaint volume.

Complaints by Component

ComponentCount
ENGINE4
ELECTRICAL SYSTEM3
BACK OVER PREVENTION: WARNINGS2
BACK OVER PREVENTION: SENSING SYSTEM: CAMERA2
POWER TRAIN2
FUEL SYSTEM, GASOLINE1
FUEL/PROPULSION SYSTEM1
SERVICE BRAKES1
BACK OVER PREVENTION: REARVIEW SYSTEM BRAKING1

Recalls (6)

23V44500026/06/2023

FUEL SYSTEM, GASOLINE:DELIVERY:FUEL PUMP

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

22V36500020/05/2022

ELECTRICAL SYSTEM:SOFTWARE

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model de

21V35400014/05/2021

BACK OVER PREVENTION: SENSING SYSTEM: CAMERA

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX m

21V52700012/07/2021

AIR BAGS:SENSOR:SIDE IMPACT

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts

22V23200008/04/2022

BACK OVER PREVENTION:DISPLAY FUNCTION

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The rearview camera may not disp

21V05800005/02/2021

ELECTRICAL SYSTEM:SOFTWARE

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle mod

Recent Complaints

20260104POWER TRAIN

With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .

20251227ENGINE

Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.

20250714ENGINE

My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road. Mercedes-Benz USA refuses to cover the repair (~$7,600+), even though it relates to a factory-documented problem. I’m requesting that NHTSA investigate this engine defect, as it may qualify for a safety recall or mandatory extended warranty coverage. INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

20250710POWER TRAIN

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

20250321ELECTRICAL SYSTEM

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

20250321BACK OVER PREVENTION: REARVIEW SYSTEM BRAKING

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

20250321BACK OVER PREVENTION: SENSING SYSTEM: CAMERA

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

20241207FireELECTRICAL SYSTEM

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.

20241207FireENGINE

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.

20240518BACK OVER PREVENTION: WARNINGS

I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.

20240518BACK OVER PREVENTION: SENSING SYSTEM: CAMERA

I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.

20240322SERVICE BRAKES

The contact owns a 2021 Mercedes-Benz E350. The contact stated that while parking the vehicle the emergency brake independently seized. The contact stated that the vehicle abruptly stopped. The vehicle would not drive forward or backward. The contact contacted the dealer and a service technician was dispatched to the location. The service technician connected the vehicle to the diagnostic equipment. The contact was advised that the vehicle was not safe to drive. The vehicle was towed to the dealer where it was diagnosed with a failed brake caliber voltage malfunction and the brake caliber voltage needed to be replaced. The vehicle was repaired. The manufacturer was made aware of the failure. The failure mileage was approximately 24,001.

Mileage: 24,001

20240209ENGINE

The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car not moving in on coming traffic Dealership is citing that is needs to have a cylinder replaced but will not tell me why it needs to be replaced, why this has happened or what could have been done pre maintenance to avoid this issue Check engine light came on Dealer has been contacted, and was told this is a common issue for this to happen to newer cars, but will not fix the issue and extended warranty will not cover due to this is a manufacturer issue

20240209ELECTRICAL SYSTEM

The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car not moving in on coming traffic Dealership is citing that is needs to have a cylinder replaced but will not tell me why it needs to be replaced, why this has happened or what could have been done pre maintenance to avoid this issue Check engine light came on Dealer has been contacted, and was told this is a common issue for this to happen to newer cars, but will not fix the issue and extended warranty will not cover due to this is a manufacturer issue

20240209FUEL/PROPULSION SYSTEM

The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car not moving in on coming traffic Dealership is citing that is needs to have a cylinder replaced but will not tell me why it needs to be replaced, why this has happened or what could have been done pre maintenance to avoid this issue Check engine light came on Dealer has been contacted, and was told this is a common issue for this to happen to newer cars, but will not fix the issue and extended warranty will not cover due to this is a manufacturer issue

20240122FUEL SYSTEM, GASOLINE

The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced. The vehicle was not repaired. The local dealer and manufacturer were notified of the failure and informed the contact that the VIN was not included in NHTSA Campaign Number: 23V445000 (Fuel System, Gasoline). The contact stated that the vehicle had experienced that failure listed in the recall. The failure mileage was 53,200.

Mileage: 53,200

20231219BACK OVER PREVENTION: WARNINGS

When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happening over the last 2 years infrequently. When the issue was brought up at the dealer during service, their recommendation was to bring the vehicle in immediately at the time it occurs, but I haven't been able to do so with work. Now this issue is happening more frequently. There is a campaign online that is for the same issue I'm having: April 1, 2021 NHTSA CAMPAIGN NUMBER: 21V228000 Rearview Camera and Parking Sensors Malfunction

Compare 2021MERCEDES-BENZE 350 to Similar Vehicles

NHTSA Investigations

View all investigations

Frequently Asked Questions

How many complaints does the 2021 MERCEDES-BENZ E 350 have?
The 2021 MERCEDES-BENZ E 350 has 17 NHTSA complaints, 0 crashes, 2 fires, 0 injuries, and 0 deaths reported.
Are there any recalls for the 2021 MERCEDES-BENZ E 350?
Yes, the 2021 MERCEDES-BENZ E 350 has 6 recall(s). The most common affected component is FUEL SYSTEM, GASOLINE:DELIVERY:FUEL PUMP. Recalls are issued by NHTSA and manufacturers must provide a free remedy.
What are the most common problems with the 2021 MERCEDES-BENZ E 350?
The most-complained component for the 2021 MERCEDES-BENZ E 350 is ENGINE with 4 complaints. Other frequently reported areas include ELECTRICAL SYSTEM and BACK OVER PREVENTION: WARNINGS.
Is the 2021 MERCEDES-BENZ E 350 safe to buy?
Review the complaint history, crash and fire reports, safety ratings, and recall status on this page to make an informed decision. No NHTSA crash test rating is available for this model year. Compare with other model years using the links above.
Where does this data come from?
All complaint, recall, and safety rating data is sourced from the National Highway Traffic Safety Administration (NHTSA). Complaints are filed by vehicle owners through NHTSA's Office of Defects Investigation.

Vehicle Safety Guides

Data as of 2025. Sources: NHTSA Office of Defects Investigation (ODI) complaints database, NHTSA recall campaign API, NHTSA NCAP crash-test ratings, and NHTSA FARS for fatality cross-reference.